Close up of a microscope with a sample
Muscle biopsy under a microscope
(Image Credit: Rob Judges / Oxford University Images)

DPhil in Biomedical and Clinical Sciences (Oxford-GSK)

About the course

The DPhil in Biomedical and Clinical Sciences (Oxford-GSK) aims to address an unmet need among clinicians for training in data science and translational medicine. The course provides a unique opportunity for clinical academics to gain early-career experience in an industry-sponsored translational medicine programme. 

This course is also known as the Oxford-GSK Doctoral Training Fellowship and is funded by GSK (GlaxoSmithKline Plc). It is aimed at fully-qualified medical doctors who are, or are eligible to be, registered clinical practitioners with the UK General Medical Council (GMC).

To apply to this course you must be medically-qualified and eligible to undertake clinical practice in the UK (having General Medical Council registration or proven eligibility for registration). You should have clinical experience at ST4+ level or equivalent, typically having obtained MRCP or equivalent, but not CCT or consultant status (see Entry requirements for further details). 

Course structure

The therapeutic areas focused on will be:

  • neurodegeneration
  • liver fibrosis
  • respiratory medicine.

Targeted Development of Data Science Capabilities

You will receive dedicated training in data science via the Oxford Biomedical Data Science Training Programme (OBDS). Specific data science skills will be determined by individual projects, but it is expected that on graduation you will:

  • be proficient in a programming language (eg R or Python)
  • understand the coding of healthcare records and approaches to access/analyses of the data
  • can select the appropriate biostatistical techniques for the analysis of real-world data and multi-omic big data
  • understand the design of machine learning approaches.

Project Parameters

It is expected that the focus of projects will be the collection, analysis and interpretation of multi-omic data, with the leveraging of existing departmental infrastructure and personnel to support any laboratory work.

Projects will focus on a patient-centric approach to understanding disease endotypes and mechanisms of disease, thus enhancing future patient stratification and precision medicine strategies in drug development.

High level examples of potential projects can be found on the Medical Sciences Doctoral Training website.

Student and employment contracts

Students will have a salaried employment contract with the University of Oxford for the three-year duration of the course. This means that students will have two contracts, both lasting three years:

  • an employment contract with the University (the terms of which will be set out at the point of their offer letter); and
  • a student contract (details of which can be found in our contract information for new students).

Each of the two contracts is conditional upon the other – if one ends for any reason then the other will normally end too. So, for example, if the student contract terminates before the scheduled expiry of the three years (eg because the student has failed to pass a required academic assessment/exam or as a result of a finding that the student has committed a serious breach of the Student Disciplinary Code) the employment contract will normally terminate, and vice versa. (In some cases, if a student is close to submission of final assessments but three years have elapsed, the student contract may be extended to enable them to finish, though the employment contract would not normally be extended in these circumstances.)

Successful applicants will be offered a salary for three years at band E63/E64 (details of the current salary scales can be found on the Finance Division website). The salary offered will reflect the applicant’s existing seniority, with consideration of the BMA’s published salary scales for resident doctors in the NHS (and for applicants from outside the UK there will be a similar consideration of the applicant’s seniority).

Successful applicants’ University tuition fees will be fully funded at the Home fee rate. Overseas students will need to pay the difference between Home fee rate and Overseas fee rate, or arrange new third-party funding themselves to cover this.

It is a pre-condition of commencing the course that the applicant must be entitled to both study and work in the UK. Applicants from overseas will need to have an appropriate visa by the point that the course commences, and if such a visa cannot be obtained then the offer will be withdrawn.

To maintain eligibility to practice with the GMC, students will arrange a separate contract with the NHS to enable them to continue clinical practice (while ensuring they dedicate most of their working time to their studies/work for the University). It is the student’s responsibility to arrange this.

Further information about this course and employment aspects can also be found on the department's website.

Attendance

The course is full-time and requires attendance in Oxford. Full-time students are subject to the University's Residence requirements.

Provision exists for students on some courses to undertake their research in a ‘well-founded laboratory’ outside of the University. This may require travel to and attendance at a site that is not located in Oxford. Where known, existing collaborations will be outlined on this page. Please read the course information carefully, including the additional information about course fees and costs.

Each project will include close working with GSK, which may require travel to and attendance at GSK offices in Stevenage, UK. 

Resources to support your study

As a graduate student, you will have access to the University's wide range of world-class resources including libraries, museums, galleries, digital resources and IT services.

The Bodleian Libraries is the largest library system in the UK. It includes the main Bodleian Library and libraries across Oxford, including major research libraries and faculty, department and institute libraries. Together, the Libraries hold more than 13 million printed items, provide access to e-journals, and contain outstanding special collections including rare books and manuscripts, classical papyri, maps, music, art and printed ephemera.

The University's IT Services is available to all students to support with core university IT systems and tools, as well as many other services and facilities. IT Services also offers a range of IT learning courses for students, to support with learning and research.

In addition to the University-wide resources described above, you will have access to experimental facilities appropriate to your research and library services such as the Radcliffe Science Library and the Cairns Library.

The provision of project-specific resources will be agreed with the relevant supervisor during the planning stages for the research project.

Supervision

For this course, the allocation of graduate supervision is the responsibility of the Medical Sciences Doctoral Training Centre, and it is not always possible to accommodate the preferences of incoming graduate students to work with a particular member of staff. Under exceptional circumstances a supervisor may be found outside the Medical Sciences Doctoral Training Centre and/or closely-related departments.

Supervision will include relevant therapeutic and data science expertise, with representation from both Oxford and GSK.

Students are expected to meet with their supervisors at least once a fortnight, on average, across a year.

Assessment

All students will be initially admitted to the status of Probationer Research Student (PRS). Within a maximum of four terms as a PRS student you will be expected to apply for transfer of status from Probationer Research Student to DPhil status.

A successful transfer of status from PRS to DPhil status will require the submission of a report on progress to date on research and future plans. Students who are successful at transfer will also be expected to apply for and gain confirmation of DPhil status within nine terms of admission, to show that your work continues to be on track.

Both milestones normally involve an interview with two assessors (other than your supervisor) and therefore provide important experience for the final oral examination.

You will be expected to submit an original thesis of up to 50,000 words after three or, at most, four years from the date of admission. To be successfully awarded a DPhil in Biomedical and Clinical Sciences (Oxford GSK) you will need to defend your thesis orally (viva voce) in front of two appointed examiners.

Graduate destinations

Most Biomedical and Clinical Sciences graduates continue in academic research in prestigious laboratories worldwide.

Changes to this course and your supervision

The University will seek to deliver this course in accordance with the description set out in this course page. However, there may be situations in which it is desirable or necessary for the University to make changes in course provision, either before or after registration. The safety of students, staff and visitors is paramount and major changes to delivery or services may have to be made if a pandemic, epidemic or local health emergency occurs. In addition, in certain circumstances, for example due to visa difficulties or because the health needs of students cannot be met, it may be necessary to make adjustments to course requirements for international study.

Where possible your academic supervisor will not change for the duration of your course. However, it may be necessary to assign a new academic supervisor during the course of study or before registration for reasons which might include illness, sabbatical leave, parental leave or change in employment.

For further information please see our page on changes to courses and the provisions of the student contract regarding changes to courses.

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